You control a semi-rigid Spider-Man, consisting of a stand-in for the protagonist and some of his signature web-shooters, as you navigate a 2D street environment. Playing Spider-Man Mysterio Rush involves navigating the web-slinging hero through the city while avoiding obstacles and far-casting your webs.
The ultimate goal is to reach the exit flags placed throughout the environment before Mysterio interferes, and the time limit is displayed in the top right of the screen. The game runs directly in the web browser, allowing for instant access without downloadable software or registration.